Tag Archives: antidepressants

Battling over happy pills

In this corner: Dr. Marcia Angell, former editor in chief of the New England Journal of Medicine, senior lecturer in social medicine at Harvard Medical School, and frequent critic of the pharmaceutical industry. In the opposite corner: Dr. Peter Kramer, Brown University psychiatry professor and author of the mega-selling “Listening to Prozac,’’ a book that helped convince thousands of Americans to live better, chemically.

At issue: a two-part article by Angell, published in The New York Review of Books, that assails psychiatrists and their pharmaceutical helpmeets, mainly antidepressants, on several fronts.

Item: Angell, quoting, among others, Tufts University psychiatrist Dr. Daniel Carlat, attacks the widely held belief that depression and other mental disorders result from chemical imbalances in the brain. Item: Citing the research of British psychologist Irving Kirsch, Angell writes that some of the most widely used antidepressants, including Prozac, Paxil, Zoloft, Celexa, and Effexor, performed only marginally better than placeItem: Angell uses a book by journalist Robert Whitaker to suggest that newly minted antipsychotic drugs may be causing “an epidemic of brain dysfunction.’’

PEOPLE’S PHARMACY:Can drugs cause violent behavior?

Americans revere personal responsibility. It resonates with our respect for accountability and frontier justice. That may explain why we have a hard time believing that medications could alter people’s personalities or lead them to behave badly. Violence as a drug side effect seems preposterous to patients, pharmacists, physicians and even juries. Trying to use the “Prozac defense” to justify killing or hurting someone is often met with scorn..

Antidepressant prescribing information, for example, warns physicians that, “All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior.” Drugs such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft) carry warnings about aggressiveness, agitation, hostility, impulsivity and irritability.

The stop-smoking medication varenicline (Chantix) also comes with warnings about agitation, hostility, depressed mood and changes in behavior. The trouble with such warnings is that people don’t imagine that these bad things could happen to them.

Antidepressant Nation

A serious conversation is under way in the United States on the subject of psychiatric drugs. The debate consists of three fundamental issues: first, whether antidepressants actually treat depression; second, the vast, growing body of evidence that psychotropic medications alter the brain permanently; and third, the pharmaceutical industry’s continuing, decades-old corruption of American psychiatrists, many of whom have been made by drug companies’ shenanigans into little more than handsomely paid industry shills.

U.S. Troops Reportedly Taking More Medication Than Ever

In 2010 a US Army study revealed how 14 percent of soldiers have been prescribed an opiate painkiller. 95 percent of those prescriptions were for oxycodone, a notoriously-addictive pharmaceutical best known by the brand name OxyContin. And since 2001, military spending on prescription medication has skyrocketed. Orders for antipsychotics like Seroquel are up 200 percent, and demand for anti-anxiety drugs like Valium has increased by 170 percent, according to Defense Logistics Agency records. Many of the antidepressants, antipsychotic drugs and anti-anxiety drugs prescribed are highly addictive. Potential side effects include dulled reaction times, irritability and a heightened risk of suicide. “The medications they use shouldn’t be so heavily prescribed in combat,” said Dr. Judith Broder, a psychiatrist and founder of the Soldiers Project, a nonprofit counseling service.

U.S. Troops Reportedly Taking More Medication Than Ever

In 2010 a US Army study revealed how 14 percent of soldiers have been prescribed an opiate painkiller. 95 percent of those prescriptions were for oxycodone, a notoriously-addictive pharmaceutical best known by the brand name OxyContin. And since 2001, military spending on prescription medication has skyrocketed. Orders for antipsychotics like Seroquel are up 200 percent, and demand for anti-anxiety drugs like Valium has increased by 170 percent, according to Defense Logistics Agency records. Many of the antidepressants, antipsychotic drugs and anti-anxiety drugs prescribed are highly addictive. Potential side effects include dulled reaction times, irritability and a heightened risk of suicide. “The medications they use shouldn’t be so heavily prescribed in combat,” said Dr. Judith Broder, a psychiatrist and founder of the Soldiers Project, a nonprofit counseling service.