GlaxoSmithKline has paid out close to $1 billion to resolve lawsuits involving Paxil since the drug came on the market in 1992, according to a December 14, 2009 Bloomberg report. But the billion dollars does not cover the more than 600 Paxil birth defect cases currently pending in multi-litigation in Pennsylvania.
Taking Prozac, Paxil, or other antidepressants from the class of drugs called selective serotonin reuptake inhibitors (SSRIs) can cause delays in lactation in new mothers and difficulty in breast-feeding newborns, a new study says. Researchers from the University of Cincinnati found SSRIs can result in delayed secretory activation after giving birth. SSRIs regulate the hormone serotonin in the body to stave off depression, but the hormone also is crucial to the breasts’ ability to deliver milk when it is needed, the study’s authors said.
Doctors still routinely reassure patients that the side-effects of antidepressants are largely mild and short term – these include drowsiness, dizziness and weight gain that become obvious in the first few weeks and can normally be reversed by trying another type of pill. Yet there is growing evidence that long-term use is linked to more serious health problems including bleeding in the gut, low sodium levels in the elderly (which can lead to falls) and increased risk of stroke. Recently it’s been claimed that some antidepressants may increase the risk of birth defects.
A study in the Journal of the American Medical Association says that SSRI’s like Paxil and Prozac are no more effective in treating depression than a placebo pill. That means they are 33 per cent effective, which is the percent of patients who will respond well to a sugar pill.
“Our data should give some pause” to doctors and patients weighing antidepressants, Robert DeRubeis, a psychologist at the University of Pennsylvania, Philadelphia, said in a telephone interview. “They should give some consideration to other alternatives.” Exercise has been shown to be helpful to stem depression, as does psychotherapy, and even “self-treatment” with the aid of the plethora of self-help literature, he said.