Sgt. Eric Layne’s death was not pretty. A few months after starting a drug regimen combining the antidepressant Paxil, the mood stabilizer Klonopin and a controversial anti-psychotic drug manufactured by pharmaceutical giant AstraZeneca, Seroquel, the Iraq war veteran was “suffering from incontinence, severe depression [and] continuous headaches,” according to his widow, Janette Layne.
AstraZeneca Plc is facing as many as 26,000 lawsuits over its antipsychotic drug Seroquel as the drugmaker prepares for its first jury trial over claims the medicine causes diabetes, according to court filings.
The marketing team sued over a drug’s alleged side effects tried to suppress key data, an ex-employee has claimed. Seroquel’s former UK medical adviser told the BBC he was pressured to approve promotional material which said weight gain was not an issue. Maker AstraZeneca, which faces fresh legal action next month, said it took concerns about its conduct seriously.
Drugmakers encouraged doctors to prescribe these drugs for children before the FDA sanctioned their use for youngsters. This was particularly troubling, given that the drugs can cause diabetes and weight gain, side effects that prompted thousands of lawsuits claiming that drugmakers tried to hide evidence of these problems.
Many states have sued over the cost of atypical antipsychotic drugs, especially the cost of treating the diabetes and metabolic disorders they cause, which has decimated Medicaid budgets. Yet now the FDA gives pharma the Christmas present of approving Seroquel and Zyprexa for children and hence, Medicaid reimbursement even as its own Division of Pharmacovigilance (DPV) reported a “a direct association between adverse metabolic effects of treatment with atypical antipsychotics” and children!